Generally the anime and manga are the same, minus color differences(anime raoh having darker skin/black hair) and the manga having a tad more violence against women and children. The only major change is the first 21 episodes of the animated series. They re-arranged the sequence of events, added some filler, and delayed the Shin fight. In the manga Ken actually fights shin at the end of volume 1, but in the anime they delay the fight and run the stuff after the Shin fight in the manga to make it look like Shin runs a major army. Other than that, everything is pretty much the same.