Been a long while it seems (I say as I've never been on here prior to the forums re-opening)
If you're in Charlotte, there's a monthly bracket called Charlotte Showdown hosted at UNC Charlotte, and the group of fighting game players who attend the school also have meets every Friday that anyone in the area can come to as long as you can find parking nearby (you can DM me for info on the precise location of the latter and other stuff that may help if interested). This is the one I personally attend.
In Greensboro area there's Warring Triad hosted by John Mizuumi (shiburizu). I believe it's also a monthly thing, and shouldn't be too far away to attend if you live in Winston-Salem. I've only been here once, for the very first one (too long of a commute for me) but I hope to go again sometime in the future.