what you have to do when drilling acrylic with a hand drill
-Predrill a piece of wood with the same sized hole as the one you need, this will be your template
-Run a pilot hole through the centre of the hole on the acrylic
-proceed to mount your template over your bit and then find the pilot hole with the bit
-clamp the template down and clamp another piece of wood on the other side of the acrylic to prevent any blowout
-drill the hole