You want the highest damage: That means you want to minimize the number of hits it takes for you to get to 2363214 (Aka daifunka, for the record), or you want to use hits that don't prorate badly, or do good damage themselves.
For example, if you hit jD > 2B > 623B > 2363214, that's 5.2k damage. However, if you do 5A 5B 2B 2C 2363214, it's only going to be around 3k, even though the super by itself is normally more than 3k.
So which one to use often depends on the matchup. The two highest damage, hit confirmable, easy options, are probably:
To counter any slow move,
2D > jD > 2B > 623B > 2363214
Or
Grab > Web nail > 2363214
Those are going to be by far the easiest to land in authentic gameplay for the least practice, and will remain practical no matter how good you get.
EDIT: If you're playing against people who don't know what an overhead is, 5C > 2363214 will do wonders too.